Abstract

We investigated the relevancy of total IgE levels and anti-profiline, birch, apple specific IgE antibodies, to clinical symptomes containing oral allergy syndrome (OAS), in 106 allergic children.
Anti-profilin specific IgE antibody was detected by Pharmacia CAP system (EIA) in 6.6% of the cases, and all of these cases were specific IgE antibodies positive to birch and apple antigen, too. But none of them showed the symptomes of OAS, when they took apples. Anti-profilin IgE antibody positive cases showed significantly higher serum total IgE levels than the cases anti-profilin IgE antibodies negative cases. And these cases were also IgE antibodies positive to many kinds of other inhalant and food antigens. The cases who were anti-profilin IgE antibody positive, showed no characteristic symptomes. But on the contrary, the cases with OAS showed significantly higher positivity of anti-profilin IgE antibody, and showed varigated symptomes even if they were anti-profilin IgE antibody negative.
These data suggested that the profilin may be related to specific IgE antibody positivity to many kinds of antigen as a panallergen, but it is not necessarily related to many kinds of allergic symptomes.