-
[in Japanese]
2001 Volume 15 Issue 1 Pages
1-8
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
9
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
10-13
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
14-20
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
Ken Nishio, Hiroshi Odajima, Sankei Nishima
2001 Volume 15 Issue 1 Pages
21-25
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
Recently the relationship between chronic airway inflammation and bronchial responsiveness in asthma has been reported. However, these relationship in childhood asthma is not so recognized. The measurement of exhaled nitric oxide (ENO) is one of the non invasive method, which is assessed airway inflammation. Therefore we evaluated the relationship between the concentration of ENO and bronchial responsiveness. In the group without inhaled steroid treatment, significant correlation were observed between the concentration of ENO and the bronchial responsiveness. Also significant correlation were observed between the concentration of ENO and the maximum %fall in FEV
1.0 by bicycle ergometer exercise test. We recognized statistically significant relationship between bronchial hyperresponsiveness and the concentration of ENO.
View full abstract
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
26-28
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
29-32
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
33
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
34-38
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
2001 Volume 15 Issue 1 Pages
39-46
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
47-53
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese]
2001 Volume 15 Issue 1 Pages
54-61
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
Masahiro Sakaguchi
2001 Volume 15 Issue 1 Pages
62-66
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
We developed new immunotherapies (peptide and DNA vaccines) for the treatments of Japanese cedar pollinosis. Oral administration of a dominant T cell epitope of a major Japanese cedar allergen (Cry j 2) induced immunologic tolerance in both Th1 and Th2 cell responses against the whole protein allergen. We found the potential for peptide-based oral immunotherapy in order to treat allergic immune response. Next, we evaluated the use of DNA immunazation by inoculating mice with plasmid DNA encoding Cry j 1 gene. This DNA vaccination suppressed IgE and IgG1 responses to subsequent alum- precipitated Cry j 1 injections. This study suggested that DNA vaccination effectively induced Cry j 1-specific Th1-type immune responses, resulting in inhibition of IgE responses to Cry j 1.
View full abstract
-
[in Japanese]
2001 Volume 15 Issue 1 Pages
67
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
Norimasa Fukuda, [in Japanese], Osamu Arisaka
2001 Volume 15 Issue 1 Pages
68-76
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
The aquaporins (water channels) are novel molecular transporters that permit water to across the epithelial and endothelial plasma membrane. Recent studies strongly suggest that an important contribution of aquaporin in the respiratory pathophysiology. This review introduces recent advances of aquaporin on fluid transport in the distal airway and lung. AQP1 expresses in microvascular endothelia in the pulmonary interstitium. AQP5 mainly exists on alveolar type I cells. AQP3 and AQP4 are at basolateral side of large and small airways. We established new biophysical and physiological methodologies that enable to evaluate active and passive water transport in human and animal distal airway. Gene knock out technique make it possible to estimate pathophysiological roles of aquaporins in murine organs. AQP1 and AQP5 had an important role in water permeability in lung, but did not in AQP3 and AQP4. All aquaporins we examined did not contribute to active ion and water transport in murine distal airway and lung. Further study requires to elucidate the role of aquaporins in airway and lung.
View full abstract
-
[in Japanese], Donald W. MacGlashan, [in Japanese]
2001 Volume 15 Issue 1 Pages
77-80
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese]
2001 Volume 15 Issue 1 Pages
81-86
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese]
2001 Volume 15 Issue 1 Pages
87-93
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
[in Japanese]
2001 Volume 15 Issue 1 Pages
94-99
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
-
Takahiro Kiyomasu, Minoru Shibata, Kazuhiro Shiraishi, Hisako Hashimot ...
2001 Volume 15 Issue 1 Pages
100-105
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
We examined the relation between the serum iron level and bronchial asthma. The red blood cell counts (RBC), hemoglobin level (Hb), and mean corpuscular volume (MCV) were determined in 29 children with bronchial asthma (21 boys, 8 girls). In addition, serum levels of iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC, =UIBC+iron), ferritin, and IgE were measured. The subjects were divided into two groups (steroid inhalation and steroid non-inhalation). The serum iron level in the steroid inhalation group was significantly lower than that in the steroid non-inhalation group. There was no difference between the groups in RBC, Hb, MCV UIBC, TIBU, ferritin, or IgE, however, the ferritin level tended to be lower in the steroid group. These results suggest that children with bronchial asthma who receive inhaled steroids have subclinical iron deficiency.
View full abstract
-
Kazue Yamada, Yutaka Morita, Atsuo Urisu, Reiko Tokuda, Yasuto Kond, [ ...
2001 Volume 15 Issue 1 Pages
106-111
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
The freeze-dried sample of heated and ovomucoid (OM)-depleted egg white previously developed by us was proved to be significantly hypoallergenic by oral challenge tests in double-blinded manner.
It was, however, difficult to be a substitution for egg white as food staff because of poor effervescency and solubility, and bad taste. Then, we have developed a simple and easy method to decrease OM content in heated egg white even at home. The OM amount in the sample proved to be effectively decreased by SDS-PAGE as compared to heated egg white. Next, we examined the allergenicity of the heated and OM-depleted egg white by double-blind, placebo-controlled food challenge using a rice dumpling containing this sample or heated egg white as positive control. A rice dumpling without egg white was used as placebo. All the subjects with positive resultes to the challenge tests with heat-treated egg white showed negative results for this sample. There was no significant decrease in protein content as compared to the heated egg white. In conclusion, the heated and OM-depleted egg white, which is able to be simpl made at home, is hypoallergenic enough to be eatable for egg-allergic patients.
View full abstract
-
[in Japanese], [in Japanese], [in Japanese]
2001 Volume 15 Issue 1 Pages
112-117
Published: April 01, 2001
Released on J-STAGE: August 05, 2010
JOURNAL
FREE ACCESS
We investigated the relevancy of total IgE levels and anti-profiline, birch, apple specific IgE antibodies, to clinical symptomes containing oral allergy syndrome (OAS), in 106 allergic children.
Anti-profilin specific IgE antibody was detected by Pharmacia CAP system (EIA) in 6.6% of the cases, and all of these cases were specific IgE antibodies positive to birch and apple antigen, too. But none of them showed the symptomes of OAS, when they took apples. Anti-profilin IgE antibody positive cases showed significantly higher serum total IgE levels than the cases anti-profilin IgE antibodies negative cases. And these cases were also IgE antibodies positive to many kinds of other inhalant and food antigens. The cases who were anti-profilin IgE antibody positive, showed no characteristic symptomes. But on the contrary, the cases with OAS showed significantly higher positivity of anti-profilin IgE antibody, and showed varigated symptomes even if they were anti-profilin IgE antibody negative.
These data suggested that the profilin may be related to specific IgE antibody positivity to many kinds of antigen as a panallergen, but it is not necessarily related to many kinds of allergic symptomes.
View full abstract
