Abstract
Gene transcription requires the presence of transcription factors and the appropriate chromatin structure which allows the transcription factors to access the target gene. The chromatin structure is regulated by epigenetic mechanisms, i. e., DNA methylation and histone modification. Epigenetics or epigenomics will solve the issues which can not be answered by genetics, genomics and proteomics regarding the pathogenesis of various intractable diseases such as asthma.
