Abstract
We studied the predictive performance of Parameter Estimation and Dosage Adjust (PEDA), a one-compartment Bayesian Patient pharmacokinetic computer program, for the therapeutic drug monitoring (TDM) of theophylline. Twelve asthmatic children (7 of whom are boys), ranging in age from 2 to 9, who received constant aminophylline infusion, were enrolled in this study. The result is that PEDA could well estimate serum theophylline concentratios in asthmatic children, although the accuracy of prediction varied according to the dosing schedule of theophylline. Therefore it is suggested that Bayesian algorithm is useful in TDM of theophylline to asthmatic children.
