Abstract
Data of serum theophylline levels from 60 asthmatic children receiving Round the Clock Therapy with sustained-release theophylline formulations were analyzed for 144 times, using microcomputer soft-ware “Theopredict-I”. As both of intrapatient variations of pharmacokinetic parameters and interpatient variations are very large, the result of a single analysis should not be used for the analysis with Baysian Method instead of population parameters generally used. Low levels of serum theophylline observed in night-time were considered to be the result of decreased absorbtion rate (AR) and increased clearance (CL) compared with those in day-time. The optimal doses calculated from the results of the analysis varied widely, suggesting that serum theophylline levels should be frequently monitored during the Round the Clock Therapy.
AR of Theodur® Tab. were significantly small when compared with that of Theolong®, in cases of Children between 4-9 years of age, and these results suggests the Theodur Tab. are of more superior sustained-release property than the Theolong Gr..
