Abstract
We utilize APR score (CRP, α1-acid glycoprotein [α1-AG], Haptoglobin [Hp]) to diagnose early neonatal infection and comprehend clinical course. We studied the relationship between α1-AG and Hp and the severity of asthma, wheezing, cough, etc.. Subjects were 91 children with asthma who visited our allergic clinic (July 1989-August 1990) and all underwent a blood exam. Marks for severity of wheezing and cough were calculated from an asthma diary. The value for Hp of a child with severe asthma was significantly lower than for one with mild asthma (P<0.05). There was a significant relationship between marks for severity of wheezing and cough and α1-AG on the 3rd day before the blood exam (P<0.05). For subjects greater than 7 years old, however, the value for Hp did not significantly decrease along with a increase in the severity of asthma (mild 120±118.5, moderate 105.5±102.6, severe 69.9±58.1mg/dl). There was a significant relationship between marks for wheezing and cough and α1-AG on the 2nd and 3rd days preceding the blood exam (P<0.05). It is considered that the values for Hp, which decreased in young children with severe asthma, suggest indirectly the value of Hp in the control of asthma
