Abstract
In the Annual Report of School Hearth Statistics in 2011, the prevalence of asthma and other allergic diseases among Japanese children has increased during the past two decades, and the use of glucocorticoids for asthma patients has so increased. However, even short-term administration of glucocorticoids is known to stunt bone growth and increase risk of fracture. At present, bisphosphonates are used as the first-line drugs for the treatment of glucocorticoid-induced osteoporosis for adult patients, whereas no evidence has been presented in children and adolescents. We evaluated effects of the bisphosphonate (risedronate) treatment on the bone changes in established glucocorticoid-induced osteoporosis growing rats. Risedronate improved the decrease in bone strength, in addition, regulates different bone turnover in trabecular and cortical bones in the growing rat mandible. In the present study, no gross histopathologic findings of bisphosphonate-related osteonecrosis were found in the rat mandible. Therefore, we need the analysis the relationship bacteria, such as those involved in periodontal diseases and osteonecrosis of the jaw in elderly patients to elucidate the pathogenesis of bisphosphonate-related osteonecrosis.
