Abstract
Pulpal reaction to GK-101 solution, which is selectively solvent to carious dentin, was histopathologically investigated using young dog teeth. Phisiological saline was used as a control. The results were as follows:
1) Experiment I: Application of the solution in the prepared cavities. No significant differences were observed between the GK-101 group and the physiologic al saline group, indicating no irritating effect on the pulp.
2) Experiment II: Application of solution after pulp exposure. It is difficult to determine the effect of the solution on the pulp, since Dycal used for pulp capping mark edly affected the pulp response.
3) Experiment III: Application of solution after pulp exposure in the root buccally through gingiva, alveolar bone, periodontal ligament, cement and dentin. The pulpal inflammatory reaction was mild and early reparative response was found, in comparison with the results of the Experiment II. Consequently, it was concluded that GK-101 solution was not irritating to the pulp.
