Abstract
The aim of this study was to investigate the effects in the administration of indomethacin which is a specific inhibitor of prostaglandins (PGs) in order to understand the role of PGs in physiologic root resorption. For this study,24 young rabbits aged 7 days which had been in utero for 31-32 days were used. The experimental group (N=12) was injected with 5.0 mg/kg indomethacin every 12 h, and the control group (N =12) was injected with normal saline solution every 12 h.4 animals of each group were sacrificed at the 9th,11th and 13th day, respectively. Their maxillary deciduous incisors embedded in paraffin were sectioned serially 7μ in thickness. From each sample was counted the number of odontoclasts appearing on the root surface and measured the volume of the root in the maxillary deciduous incisor.
