Abstract
The aim of the present study was to confirm whether prostaglandin (PGs) had any connection with physiological root resorption.
16 young rabbits aged 7 days which had been in utero for 32 days were used and were divided into 4 groups. The control group was injected with normal saline solution, and the experimental groups were injected with indomethacin, a specific inhibitor of PGs synthetase, in doses of 0.1 mg/kg,1.0 mg/kg,10.0 mg/kg every 12 hours for 5 days, respectively. All animals were sacrified at 11 days postnatal. Their maxillary deciduous incisors were embedded in paraffin and sectioned serially in 7μ thickness. The number of odontoclasts appearing on the root surface were counted, and the volume of the maxillary deciduous incisor was measured.
