ビンロウジについて(2)　クリーンアナリシスを指向した分析法の検討

田上 貴臣; 有本 恵子; 石原 理恵; 伊藤 美千穂; 居村 克弥; 大井 逸輝; 岡坂 衛; 河端 昭子; 酒井 英二; 嶋田 宏志; 嶋田 康男; 高井 善孝; 西尾 雅世; 野村 涼坪; 松田 久司; 松本 卓也; 守安 正恭; 山本 豊; 横倉 胤夫

doi:10.24684/jspharm.72.1_21

Originals

Studies on Arecae Semen

Takaomi Tagami, Keiko Arimoto, Rie Ishihara, Michiho Ito, Katusya Imura, Itsuki Oi, Mamoru Okasaka, Akiko Kawabata, Eiji Sakai, Hiroshi Shimada, Yasuo Shimada, Yoshitaka Takai, Kayo Nishio, Ryohei Nomura, Hisashi Matsuda, Takuya Matsumoto, Masataka Moriyasu, Yutaka Yamamoto, Tsuguo Yokokura

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Keywords: Arecae Semen, clean analysis, HPLC, quantitative analysis

JOURNAL FREE ACCESS

2018 Volume 72 Issue 1 Pages 21-27

DOI https://doi.org/10.24684/jspharm.72.1_21

Details

Abstract

The origin of Arecae Semen is a seed of Areca catechu Linné (Palmae) and it is used as an ingredient of Kampo formulae such as Kumibinroto and Nyoshinsan. The seed contains alkaloids such as arecaidine, arecoline, guvacoline and guvacine. Arecaidine, arecoline and guvacine in Arecae Semen can be analyzed on HPLC with solvent containing sodium lauryl sulfate as a mobile phase. However, this method is not very convenient mainly because of the bubbles of sodium lauryl sulfate. In this study, a new method for HPLC analyses of arecaidine, arecoline and guvacine in Arecae Semen without the use of sodium lauryl sulfate was investigated. Finally, a new method using perchloric acid as a mobile phase was developed.

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