Chemical Constituents from the Aerial Parts of Achillea millefolium and Their Aldose Reductase Inhibitory Activity

Tomoki Iguchi; Minpei Kuroda; Kei Narita; Yoshihiro Mimaki

doi:10.24684/jspharm.73.2_91

天然薬物ノート

Chemical Constituents from the Aerial Parts of Achillea millefolium and Their Aldose Reductase Inhibitory Activity

Tomoki Iguchi, Minpei Kuroda, Kei Narita, Yoshihiro Mimaki

著者情報

キーワード: Achillea millefolium, aldose reductase, flavone derivative, quinic acid derivative, sesquiterpene derivative

ジャーナルフリー

2019 年 73 巻 2 号 p. 91-92

DOI https://doi.org/10.24684/jspharm.73.2_91

詳細

抄録

The MeOH extract prepared from the aerial parts of Achillea millefolium showed potent aldose reductase (AR) inhibitory activity. Bioassay-guided fractionation of the extract resulted in the isolation of a previously undescribed flavonoid glycoside (1), as well as eight known flavonoid derivatives (2－9), caffeic acid (10), two known quinic acid derivatives (11 and 12), and two known sesquiterpene derivatives (13 and 14). Compounds 1－3, 8, 9, 11, and 12 showed AR inhibitory activity with IC₅₀ values ranging from 3.4 μM to 29.2 MM.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）