A case of amenorrhea in childhood due to bilateral recurrent ovarian mature teratoma

Abstract

Ovarian mature teratomas are prevalent benign tumors in childhood, often necessitating tumor enucleation to preserve fertility in cases of recurrence or metachronous growth. This study presents the case of a 2-year-and-2-month-old girl who was referred due to an abdominal tumor discovered during a fever examination. Tumor markers were negative, and CT scans revealed an 8 cm calcifying cystic tumor, indicating ovarian mature teratoma. A left ovarian tumor enucleation was performed and pathologically confirmed. At the age of 9 years and 1 month, a contralateral tumor was enucleated from the right ovary, recurring at 10 years and 10 months. While menarche occurred at 12 years and 1 month, another left ovarian tumor recurrence appeared at 12 years and 5 months. The disease progressed to amenorrhea at 13 years and 9 months, leading to premature ovarian failure by 14 years and 6 months. This study emphasizes the significance of fertility preservation in cases of bilateral ovarian teratomas.