Intradical injection for the treatment of lumbar intervertebral disc herniation: A Multicenter Study

Abstract

Chemonucleolysis with condoliase has been anticipated as a novel therapy for lumbar intervertebral disc herniation. A total of 124 cases treated with intradiscal injection with condoliase and followed for at least 6 months after the injection in 5 institutions were reviewed. Ninety-seven patients had sufficient relief of the lower extremity pain caused by radiculopathy, although 6 cased underwent herniotomy even after the injection therapy within 6 months. Approximately 80% of patients in whom limb pain was reduced to 50% compared to that before the injection obtained pain relief within 3 months after intradiscal injection.