Rhabdomyosarcoma with TFCP2 rearrangement with prominent epithelioid arrangement:A case report

Abstract

The patient was a female in her 50s.　A mass lesion with bone destruction was found in the right maxilla.　Macroscopically, the mass was grayish-white in color with indistinct borders with the surrounding area.　Histologically, atypical large cells with well-defined nucleoli and eosinophilic cytoplasm were proliferating in a cord-like or solitary arrangement, similar to epithelioid rhabdomyosarcoma.　However, atypical cells showed positive staining of ALK, and FISH revealed TFCP2 split signals and FUS-TFCP2 fusion signals, which confirmed the diagnosis of rhabdomyosarcoma with TFCP2 rearrangement.