A case of pediatric follicular thyroid carcinoma with DICER1 somatic mutation and lymph node metastasis

Abstract

The patient was an 8-year-old girl.　She underwent right lobectomy and lymph node dissection for right thyroid follicular carcinoma, and lymph node metastasis was found from the time of the initial surgery.　Genetic testing detected a somatic DICER1 mutation.　Germline DICER1 mutations were not tested.　After surgery, the patient developed progressive lymph node metastasis and recurrence, requiring additional treatment.　This case is noteworthy in that it is the first reported case of pediatric follicular thyroid cancer with a DICER1 mutation and lymph node metastasis.　It is also the third youngest reported case of follicular thyroid cancer with a DICER1 mutation.