Palliative Care Research
Online ISSN : 1880-5302
ISSN-L : 1880-5302
Case Reports
Effect of tramadol on cancer pain in a patient with advanced endometrial carcinoma and myasthenia gravis: a case report
Yoshihiro Yamamoto, Maki Todo, Kikuyo Nishida, Keita Iwasaki, Chiharu Suzuki, Miki Kondo, Shoko Kinoshita, Kazuyo Kanbara, Hiromitsu Yabushita, Akihiko Wakatsuki, Katsuhiko Matsuura, Mari Nishihara, Kenichi Arai
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Keywords: myasthenia gravis, tramadol, anticholinergic effect, cancer pain
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2013 Volume 8 Issue 2 Pages 570-574

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Abstract
Introduction: Tramadol (TRM) has been included as a weak opioid at the second step of the WHO analgesic ladder and has been widely used in palliative medicine. Here we report a case of amelioration of cancer pain by TRM therapy in a female patient with myasthenia gravis (MG). Case:The patient was a 70’s woman who was diagnosed with advanced endometrial carcinoma and suffered from chest pain caused by chest metastasis. 25 mg of a TRM capsule was orally administered three times a day. The dose was increased to 50 mg twice a day. It was resulted in sound pain relief with transient muscle weakness but without a myasthenic crisis.
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© 2013 by Japanese Society for Palliative Medicine
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