抄録
Oxidative stress is one of the major environmental factors for all living organisms. DNA microarray analysis revealed that incubation of cyanobacterial cells of Synechocystis sp. PCC 6803 with 0.25 mM H2O2 dramatically changed the pattern of genome-wide expression of genes. It induced the expression of 225 genes and repressed the expression of 320 genes. Screening of the mutant libraries of histidine kinases (Hik) by means of the H2O2-inducible expression of genes revealed that four histidine kinases, Hik33, Hik34, Hik2, Hik41 and a transcription factor PerR are involved in the perception of H2O2 signals and in the regulation of the H2O2-inducible expression, with induction factors higher than four, of 25, 1, 6, 2 and 6 genes, respectively. Further analysis will be discussed.
