Molecular dissection of CLV3 signalling

Abstract

In Arabidopsis, the CLAVATA (CLV) pathway operates in the regulation of the size of the stem cell population in the shoot apical meristem. CLV3 was shown to function as a dodecapeptide and is considered as a ligand for receptor complex(es) containing CLV1 and CLV2. Recent studies have identified a new member of receptor, Suppressor of Overexpression of LLP1-2 (SOL2)/CORYNE (CRN), capable of sensing the CLV3 peptide. Our current project aims to understand the precise molecular details of CLV3 signalling mediated by these receptor-like proteins in a target cell. We are conducting biochemical studies on these receptor functions. Our various mutational screenings for the CLV3 synthetic peptide insensitivity identified a number of potential candidates. Current progress in this study will be presented.