2026 Volume 42 Issue 1 Pages 5-12
Neuroimaging of pediatric central nervous system infections and acute encephalopathy has been transformed by advances in vaccination, evolving epidemiology (notably post-COVID-19), new disease concepts, and imaging technology. This review highlights recent developments, including the characteristics and latest findings concerning fetal inflammatory response syndrome (FIRS) and congenital cytomegalovirus (CMV) infection. We also discuss the establishment of infection-triggered encephalopathy syndromes (ITES) as a new conceptual framework.