抄録
Aim: To test the hypothesis that lipocalin-type prostaglandin D synthase (L-PGDS), a marker of vascular endothelial cell disorders, may be a diagnostic for preeclampsia.
Methods: Plasma and urine were collected from 36 preeclamptic patients and 94 normal pregnant women. L-PGDS concentrations were determined by sandwich ELISA assay. Receiver operating characteristic (ROC) curve validated the cut-off point of the assay.
Results: The plasma and urinary L-PGDS concentrations were significantly higher in the preeclamptic patients than the normal pregnant women. Urinary L-PGDS concentrations of the normal pregnant women were higher in the third trimester compared to earlier pregnancy, while plasma concentrations remained unchanged. Urinary L-PGDS levels were significantly higher in early onset of preeclampsia (onset <32 weeks gestation) compared with late onset and in the severe compared to mild preeclampsia. ROC curve showed the cut-off point of 58.85 μg/dl (sensitivity 76.5%, specificity 75.6%, positive predictive value [PPV] 46.4%, negative predictive value [NPV] 92.1% and area under the curve [AUC] 0.82) in the plasma and 2.195 μg/dl (sensitivity 84.6%, specificity 58.7%, PPV 33.8%, NPV 93.8% and AUC 0.76) in urine.
Conclusions: Our results indicate that plasma and urinary concentrations of L-PGDS may be a potential diagnostic for preeclampsia.
