論文ID: HRP2021-009
Pseudohypoaldosteronism type 2 (PHA2) is an extremely rare autosomal dominant disease characterized by salt-sensitive hypertension with hyperkalemia which develops at a young age. This report describes for the first time the perinatal course and outcome of pregnancy in a woman and her children with PHA2. A 33-year-old woman with PHA2 presented with exacerbated hypertension and hyperkalemia from mid-pregnancy and was treated with thiazide diuretics in her two pregnancies. She developed superimposed pre-eclampsia only during her first pregnancy; fetal growth restriction was observed in both pregnancies. Both of her neonates developed hypertension and electrolyte imbalances and were diagnosed with PHA2 by genomic analysis. If a pregnant woman develops hypertension with hyperkalemia, PHA2 should be suspected, and both the mother and her infant should be managed carefully.
