Laparoscopic hepatectomy for HCC in malnutrition patients at our hospital

Abstract

In this study, we evaluated the operation outcome, disease‐free survival（DFS），and overall survival（OS）after hepatectomy in malnutrition patients with hepatocellular carcinoma（HCC）．Between June 2010 and October 2017, 283 hepatectomies for HCC were performed at our hospital. The Controlling Nutritional Status（CONUT）Score was measured in these patients and 161 HCC patients with malnutrition underwent laparoscopic hepatectomy. The Child‐Pugh classification（A/B/C）in the malnutrition group（n＝161）vs the non‐malnutrition group（n＝102）was 143/18/0 vs 102/0/0（p＜0.0001），liver damage score（A/B/C）was 91/68/2 vs 95/7/0（p＜0.0001），BMI was 23.2 kg/m2 vs 24.6 kg/m2（p＝0.0043），PNI was 43.4 vs 50.3（p＜0.0001），pStage（I/II/III/IV）was 49/67/34/10 vs 33/51/11/7（p＝0.1732），operation time was 318.2 minutes vs 356.7 minutes（p＝0.0128），blood loss volume was 356.8 ml vs 248.3 ml（p＝0.3742），and the hospital stay after the operation was 16.2 days vs 11.8 days（p＝0.3137），respectively. The 1‐year DFS rate was 72.6％and 87.5％，2‐year DFS rate was 50.9％and 70.9％（p＝0.0058），1‐year OS rate was 81.7％and 96.4％，and 2‐year OS rate was 73.5％and 88.7％（p＝0.0021），respectively. Although laparoscopic hepatectomy for malnutrition patients was safe and feasible, they had a poor prognosis.