The Japanese Journal of SURGICAL METABOLISM and NUTRITION
Online ISSN : 2187-5154
Print ISSN : 0389-5564
ISSN-L : 0389-5564
Why did the “ESSENSE Project Multicenter Prospective Clinical Trials” fail to produce positive results?
Masaki KaiboriGo MiyataHideki TaniguchiYoshihiro NabeyaKazuhiko FukatsuNaohiro WashizawaHisashi KosakaRyoji Fukushima
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2021 Volume 55 Issue 6 Pages 221-227

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Abstract

The Japanese Society of Surgical Metabolism and Nutrition launched the ESSENSE project in 2012. A prospective multicenter study was conducted in 2014 to examine whether the project measures actually improve patient satisfaction and promote physical recovery. Esophagectomy, total gastrectomy or gastrectomy, pancreatoduodenal resection, hepatectomy, and colectomy were the target surgical procedures. As a control period, the perioperative period management at each facility was set to 6 months. After that, the intervention period was 6 months for perioperative management by ESSENSE intervention, and a prospective cohort study comparing before and after the intervention for each surgical procedure. Quantitative evaluation of patient satisfaction using the question method QoR40 on the 3rd and 7th postoperative days showed no improvement in QoR40 in the intervention group in 5 target surgical procedures. There were no differences between the two groups in biochemical laboratory data, postoperative complication rate according to Clavien‐Dindo classification, length of stay, and medical expenses for each surgical procedure. One of the reasons why better perioperative management results could not be obtained in the ESSENSE intervention group was that the patient’s own ESSENSE diary was insufficient for patient satisfaction in QoR40. It was speculated that the QoR40 result itself in the non‐intervention group was not low, and that the setting of the additional effect itself was a problem. It was also considered that this intervention was insufficient for early independence of physical activity and early independence of nutrition intake.

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