Effects of enteral nutrition formulas with different amounts of carbohydrate on glycemic control in diabetic mice

Abstract

［Objective］ The aim of the present study was to compare the effects of long‐term use of two enteral nutrition formulas with different amounts of carbohydrate （64％ in Hine‐Egel ［standard type：ST］） and 50％ in Hine‐Egel LC ［low‐carbohydrate type：LC］） on glycemic control parameters in diabetic mice for 8 weeks. ［Methods］ Eight‐week‐old male db/db mice orally took either the ST or LC formula ad libitum for 8 weeks. ［Results］ HbA1c during the study tended to be lower and plasma glucose and glycoalbumin 8 weeks after feeding were significantly lower in the LC group when compared to the ST group. ［Conclusion］ These findings suggest that enteral nutrition formula with low carbohydrate content enables to decrease both plasma glucose and glycated albumin in diabetic mice 8 weeks after feeding.