2015 年 50 巻 2-3 号 p. 175-178
【Objective】To scrutinize the status of lung transplantation in Japan, the Japanese Society of Lung and Heart-Lung Transplantation started to collect and present registry data from 2005. This is the 11th official registry report of Japanese lung transplantation.
【Design and Methods】The data of cadaveric lung transplantation and living-donor lobar lung transplantation performed by the end of 2014 were registered in the database and analyzed with respect to the number of transplants, recipient survival rates, recipient functional and working statuses, and causes of death after transplantations. Survival rates were calculated by the Kaplan-Meier method.
【Results】A total of 238 cadaveric lung transplantation (127 single, 111 bilateral), 165 living-donor lobar lung transplantation and 2 heart-lung transplantation procedures were performed by the end of 2014. Five-year and 10-year survival rates of cadaveric lung transplantations were 72.1% and 59.2 %, which were superior to those in the International Registry (52.8% and 31.1%). Five-year and 10-year survival rates of living-donor lobar transplantations were similar to those of cadaveric lung transplantation with 71.9% and 65.1%. The recipients of 2 heart-lung transplantations are alive. The functional status of more than 80% of recipients was restored to Hugh-Jones I or II after transplantations. Infection has been the leading cause of death after lung transplantation. Primary graft dysfunction accounts for about 25% of the causes of death after cadaveric and living-donor lung transplantations.
【Conclusion】The outcomes of Japanese lung transplantation are so far satisfactory. Efforts must be made, however, to overcome early deaths resulting from primary graft dysfunctions. The modified Japanese transplantation law has been enforced since July, 2010, and an increase in the number of cadaveric organ transplantations has been achieved thereafter. The Japanese Society of Lung and Heart-Lung Transplantation will continue to present annual reports of Japanese lung transplantations.
