2016 年 51 巻 4-5 号 p. 331-340
The early outcomes of kidney transplantation in Japan have been improved with the development of immunosuppressive therapy. However, we have other problems such as chronic rejection, death with functioning graft (DWFG) and so on, that prevent long graft and patient survival. Some chronic rejection have immuno-reactive factors leading to graft loss, for which we have no established strategy. A novel immunosuppressant should be developed. Deaths of kidney transplant recipients have been caused by malignant disease, cardiovascular disease (CVD) and others. Preemptive kidney transplantations (PEKT) have been increased to avoid dialysis complications leading to CVD. For malignant disease, some strategies related with appropriate surveillance and necessary minimum immunosuppressive therapy should be established.
