マージナルドナーからの脳死膵臓移植の成績

抄録

【Objective】The ratio of marginal donors (MD) is high in the field of pancreas transplantation from brain-dead donors in Japan because of the small number of donors. The aim of this study was to reveal the clinical outcome of pancreas transplantation from MD.
【Design】Retrospective case series.
【Methods】This study included 38 patients who underwent pancreas transplantation from brain-dead donors. The cumulative survival rates of the patients and pancreas grafts were retrospectively evaluated between the MD group and non-MD (NMD) group according to the Pittsburgh criteria and Minnesota criteria. Moreover, the survival rate of the pancreas grafts was retrospectively evaluated between patients with cerebrovascular disease (CVD group) and those without CVD (non-CVD group). Details of the cause of death were also analyzed with special reference to CVD.
【Results】The cumulative survival rate of the pancreas grafts was 88.1% at 1 year, 77.0% at 3 years, and 73.9% at 5 years (n = 38) among patients who underwent pancreas transplantation from brain-dead donors. The survival rates of the patients and pancreas grafts were not significantly different between the MD and NMD groups as defined by the Pittsburgh criteria and Minnesota criteria. Also, no significant difference resulted in the survival rate of the pancreas grafts between the CVD and non-CVD groups.
【Conclusion】Pancreas transplantation from MD is acceptable in terms of both patient survival and graft survival.