特集「ヒト臓器の創出に向けた基礎科学」
腸管上皮オルガノイドを用いた細胞移植療法の展望
キーワード:
intestinal organoid,
transplantation,
induced pluripotent stem cell,
inflammatory bowel disease
2017 年 52 巻 4-5 号 p. 332-338
詳細
2017 年 52 巻 4-5 号 p. 332-338
Organ transplantation is a promising therapy for organ failure and defects of organ specific functions. However, the transplantation of a small or large intestine is difficult to perform partly because of the shortage of donor organs. Alternatively, organoid transplantation is becoming another choice for restoring organ-specific functions. For example, the recent development of 3-D-culture technique for intestinal stem cells has opened up our way to apply those cultured cells to tissue-regenerative therapies. Here we present a short review of studies regarding intestinal organoids established from somatic stem cells or otherwise from pluripotent stem cells. Also, we wish to discuss the possibility of using intestinal organoids as a novel tool for regenerative medicine.
