特集「日本移植学会 2017年症例登録 統計報告」
膵島移植症例登録報告（2018）
キーワード:
Japanese Pancreas and Islet Transplantation Association,
clinical trial,
islet transplantation,
type 1 diabetes
2018 年 53 巻 2-3 号 p. 149-156
詳細
2018 年 53 巻 2-3 号 p. 149-156
Islet transplantation is promising to be capable of relieving glucose instability and improving QOL of type 1 diabetic patients whose severe hypoglycemic unawareness cannot be controlled. In Japan, a phase II clinical trial of islet transplantation for type 1 diabetes patients has been started using ATG induction and a TNF-α inhibition protocol. Primary endpoints for this trial are the proportion of subjects with HbA1c<7.4% who are free of severe hypoglycemic events one year after the first islet cell infusion. This trial will play an important role in establishing islet transplantation in Japan.
