2021 年 56 巻 3 号 p. 245-251
【Objective】 To scrutinize the status of lung transplantation in Japan, the Japanese Society of Lung and Heart-Lung Transplantation started to collect and present registry data in 2005. This is the 17th official registry report of Japanese lung transplantation.
【Design and Methods】 The data of cadaveric lung transplantation and living-donor lobar lung transplantation performed by the end of 2020 were registered in the database and analyzed with respect to the number of transplants, recipient survival rates, recipient functional and working statuses, and causes of death after transplantations. Survival rates were calculated by the Kaplan-Meier method.
【Results】 A total of 584 cadaveric lung transplantation (306 single, 278 bilateral), 251 living-donor lobar lung transplantation and 3 heart-lung transplantation procedures were performed by the end of 2020. The number of cadaveric lung transplantations in 2020 was lower than in 2019 due to the pandemic of COVID-19. Five-year and 10-year survival rates of cadaveric lung transplantations were 73.0% and 60.7%, which were superior to those in the international registry. Five-year and 10-year survival rates of living-donor lobar transplantations were similar to those of cadaveric lung transplantation with 73.3% and 61.6%. The 3 recipients of heart-lung transplantation are all alive. The functional status of approximately 80% of recipients was restored to grade 0 or 1 of the mMRC scale after lung transplantations. The mMRC of the 3 heart-lung transplant recipients was grade 0. Infection has been the leading cause of death after lung transplantation. The number of deaths from chronic lung allograft dysfunction, malignancy and post-transplantation lymphoproliferative disease have been increasing in recent years.
【Conclusion】 The outcomes of Japanese lung transplantation are so far satisfactory. The modified Japanese transplantation law has been enforced since July 2010, and an increase in the number of cadaveric organ transplantations was achieved thereafter. The number of cadaveric lung transplantation in 2020 seems to have been affected by the pandemic of COVID-19. The Japanese Society of Lung and Heart-Lung Transplantation will continue to present annual reports of Japanese lung transplantations.
