（Secondary Publication）膵臓移植における移植時レシピエント年齢と移植後予後との関連性に関する検討

抄録

【Objective】 The current study aimed to clarify the influence of recipient age on PT outcomes and to identify the prognostic factors for older recipients.

【Methods】 We retrospectively analyzed the outcomes of PT in recipients aged ≥50 years (older group; n=94) in comparison with those aged <50 years (younger group; n=285) using the Japanese database. Prognostic factors in the older group were analyzed by a logistic regression model. The influence of recipient age on survival outcomes was analyzed using propensity score matching.

【Results】 The patient survival rate was significantly poorer in the older group (P<0.001). The surgical complications were comparable between the groups. Patient death due to infection or/and multiple organ failure or cardiac/cerebrovascular events was more frequently seen in the older group than in the younger group (P=0.012 and P=0.045, respectively). Multivariate analysis revealed that a longer duration of diabetes was an independent risk factor of 1-year mortality in the older group. In a propensity score-matched comparison, the patient survival rate of older recipients (n=77) was significantly poorer than that of younger recipients (n=77) (P=0.026).

【Conclusion】 PT should be considered with appropriate caution, especially for older recipients with a long duration of diabetes.