2023 年 58 巻 3 号 p. 219-225
【Objective】 This paper presents the 19th official registry report on lung transplantation in Japan, conducted by the Japanese Society of Lung and Heart-Lung Transplantation since 2005.
【Design and Methods】 The study analyzed data from cadaveric lung transplantation, living-donor lung transplantation, and heart-lung transplantation performed until the end of 2022. The data included transplant numbers, recipient survival rates, functional and working statuses, and causes of death. Survival rates were calculated using the Kaplan-Meier method.
【Results】 By the end of 2022, a total of 752 cadaveric lung transplantations (398 single, 354 bilateral), 284 living-donor lung transplantations, and 3 heart-lung transplantations were performed. The number of cadaveric lung transplants reached a record high of 108 in 2022. The 5-year and 10-year survival rates for cadaveric lung transplantations were 73.9% and 62.6%, respectively, surpassing international registry data. The survival rates for living-donor transplantations were similar to those of cadaveric lung transplantation, with 73.5% and 62.1%. All three heart-lung transplant recipients are alive. Approximately 80% of cadaveric lung transplant recipients achieved an mMRC scale grade of 0 or 1, as did approximately 75% of living-donor lung transplant recipients. Infections were the leading cause of death after lung transplantation, while deaths related to chronic lung allograft dysfunction, malignancy, and post-transplantation lymphoproliferative disease have increased in recent years.
【Conclusion】 The outcomes of lung transplantation in Japan have been satisfactory. Since the implementation of the modified Japanese transplantation law in July 2010, the number of cadaveric lung transplantations has increased. Although the number of transplants decreased in 2020 due to the COVID-19 pandemic, it recovered in 2021 and reached a record high in 2022. The Japanese Society of Lung and Heart-Lung Transplantation will continue to provide annual reports on Japanese lung transplantations.
