A case of cerebral amyloid angiopathy presented as subcortical brain hemorrhage in a young adult who underwent head trauma surgery using cadaveric dural graft in childhood

Abstract

Cerebral amyloid angiopathy (CAA) rarely occurs under the age of 55. An association between neurosurgical procedure in childhood and CAA has been reported. We experienced a case of juvenile CAA having presented as subcortical hemorrhage, and here report it with literature reviews. The patient was a 37-year-old man who underwent reconstruction of the dura mater using cadaveric dural graft in head trauma surgery at the age of 1. Since no specific abnormality was found for scrutinization of the cause of brain hemorrhage, we performed hematoma evacuation in the left temporoparietal region. He was diagnosed with CAA pathologically by the biopsy in the secondary operation. The brain surgery using cadaveric dural graft was thought to be related to the deposition of Aβ.