Abstract
To assess the incidence of stroke in subjects with silent brain infarction (SB1) which were found by health screening of the brain using MRI, we performed a follow-up study by questionaire in 582 subjects without stroke and 28 with minor stroke. The incidence of SBI was found to be 15.7%, Development of stroke was observed in 4 of 467 subjects without SBI (0.86%), 6 of 87 with SBI (6.9%), and 3 of 28 patients with minor stroke (10.7%). Periventricular hyperintensity was not related to the development of stroke. There were 8 patients with brain infarction and 2 with brain hemorrhage. Hypertension and older age were significantly related to the development of stroke. Multivariate analysis demonstrated that the subjects with SBI formed a significantly high risk group for stroke.
