Uirusu
Online ISSN : 1884-3433
Print ISSN : 0042-6857
ISSN-L : 0042-6857
SUGIURA Memorial Incentive Award for Young Virologist, The Japanese Society for Virology, 2017
Functional analysis of Host proteins involved in RNA virus replication
Seiya YAMAYOSHI
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JOURNAL OPEN ACCESS

2018 Volume 68 Issue 1 Pages 71-78

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Abstract
Since RNA virus genome encodes only a limited number of viral proteins, replication of RNA virus mostly relies on host cells. Elucidation of host proteins that play important roles in the virus replication cycles contributes not only to fundamental virology research but also to applied research such as development of antiviral drugs. We revealed that Ebola virus matrix protein VP40 utilized host COPII transport machinery for its intracellular transport to the plasma membrane. Second, we demonstrated that enterovirus A71 used Scavenger receptor class B member 2 (SCARB2) as a cellular receptor. Finally, we found that host protein CLUH played an important role in the subnuclear transport of influenza virus ribonucleoprotein (vRNP) complexes. Here, I would like to briefly introduce these findings.
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© 2018 by The Japanese Society for Virology
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