Abstract
Herpes simplex virus (HSV) is one of the most extensively studied members of the family Herpesviridae and causes various human mucocutaneous diseases, such as herpes labialis, genital herpes, herpes whitlow, and keratitis. HSV also causes herpes simplex encephalitis, which can be lethal or result in severe neurological conditions in a significant fractions of cases, even with anti-viral therapy. Thus, despite the development of several anti-herpetic drugs, numerous substantial unmet medical needs exist with regards to HSV infections. Furthermore, genital herpes infections increase the likelihood of HIV infections and its transmission by 2- to 4-fold. This review discusses recent advances in basic research on HSV, primarily focusing on our recent studies, and the implications of our findings for the development of novel therapeutic and prophylactic agents for HSV infections.
