Abstract
Cervical cancer is primarily caused by infection with the human papillomavirus (HPV) and has become a disease that can be effectively prevented through vaccination and cervical screening. This review briefly summarises the virological background, development process, and actual implementation of HPV prophylactic vaccines, which are a key pillar of prevention. With prophylactic HPV vaccination and cervical screening, the incidence of HPV-related cancers is expected to decrease significantly. The ultimate goal is to achieve a society with “One Less Worry” about HPV infections and the cancers they cause.