抄録
It is the well established fact that after the recovery from the typical course of the Tsutsugamushi disease the patients acquire the solid immunity against it which was proved to last at least for a decade or thereover. However, in regard to the aspect of the immunity development in the case in which the disease was suppressed with antibiotics as soon as the specific symptoms became manifest, there remains much to be made clear.
The author, in order to make this aspect clear, made some trials on human beings. Namely the patients of general paralysis, which had to receive the fever treatment, were infected with the inoculation of the virus of the Tsutsugamushi disease, Pescadores strain, of certain titer of mouse LD 50, and received the drug therapy with antibiotics to recovery at the various stadium of the disease. The investigation of the immunity development just mentioned was performed upon them. A part of the results obtained is presented preliminary in this paper as the first report. Namely it can be described summarily as follows.
1. The experimental minimal infectious dosis (M. I. D) of the virus of the Tsutsugamushi disease to human beings is of approximate value to mouse LD 50 titer of it.
2. Below the M. I. D., the virus cannot elicit the immunity development at all in the human body, althogh it had certainly invaded into it.
3. The specific symptoms of the disease become just manifest when the invaded virus multiplied somewhere in the body to such an extent to elicit the rickettsiemia of approximately 10-2 LD 50.
4. The patient is far more sensitive to the drug therapy with antibiotics at the height of the disease or still later than at the beginning of it.
5. The specific reaction of the site of the skin, where the virus had certainly been inoculated, can sometimes be failed, though the inoculated person contracted the disease typically.
6. A certain correlation can be observed between the length of duration of the disease and the degree of rise of OXK agglutinin titer.
