細菌ウイルスの増殖と突然変異に就て …ウイルスの増殖様式の遺伝学的解析…

抄録

From the quantitative analysis on the clonal distribution of plaque type mutants of T 2 L phage, Luria has led an interesting hypothesis on the mode of replication of virus genes. That is, the replication rate of the genetic determinants will be exponential if each replica acts as a source of new replicas. Assuming the constant probability of mutation per individual genetic markers, therefore, mutant phage will appear clonally in the host cells with the frequency which is inversely proportional to the number of mutants.
The present paper represents some experiments designed for testing the generalization of Luria's theory using another bacteriophage system with respect to the another type of mutation, i.e., host range mutation. The bacteriophage system used here, P6 phage and its host Escherichia coli, E6 strain, is suitable for analysis on the host range mutation because of its high mutation rate (10^-6).
The experimental results described in this paper showed clearly that Luria's theory holds for our bacteriophage system as to host range mutation indicating that the multiplication of vegetative phage particles of P6 is likewise exponential.