Abstract
Egg-propagated Newcastle disease virus (NDV), Miyadera strain, was neuropathic for mice in low and high dilutions. Multiplication of virus or incomplete virus synthesis did not occurred in the brain, and the disease was not transmissible by serial passage in mice.
Neuropathic effect would be caused by different activity from HA, infectivity, and hemolytic activity of the virus.
The effect seemed to parallel with the lung consolidation effect and the intestinal hemorrhage producing effect of virus in mice.
Prior intra-abdominal injection of chlorpromazine reduced the death ratio of mice resulting from the intracerebral inoculation of NDV.
Decrease of infectivity titer and relative increase of neuropathic effect of the virus were resulted from the sonic vibration.
The supernatant fluid of sonically vibrated virus preparation was neuropathic for mice even after the complete removal of the hemagglutinin.
