1959 Volume 9 Issue 2 Pages 133-138
In order to study on causal relation between polio virus and Guillain-Barré Syndrome encountered in the Setouchi area in 1953-1955, the comparative investigation of the isolation of polio virus from feces of patients with paralytic poliomyelitis and with G-B syndrome were attempted by means of roller tube cultures of human embrionic skin muscle.
7 strains of polio virus were isolated from feces of 9 polio patients and, of these, 5 were idemtified as type 1 and 2 as type 3; No viruses of the type 2 group were isolated from the material studied.
Only one strain of virus was isolated from feces of 9 G-B syndrome patients. However, this virus was not polio virus but ECHO virus. No polio virus of any type was isolated from feces of all G-B syndrome patients.
By referring to the study on the presence of the polio neutralizing antibody in the group of patients with paralytic poliomyelitis and of patients with the polyradiculoneuritis so-called G-B syndrome by Oyama, the Study on the interference phenomena between polio virus and Coxsackie virus by Ohara and above mentioned results, the pathogenesis of G-B syndrome was discussed.
