1959 Volume 9 Issue 2 Pages 199-209
Employing HVJ (Obayashi strain) vaccine inactivated with 1:10, 000 dilution of MERZONIN (sodium ethylmercurithiosalicylate), the pattern of the antibody production was observed on 50 healthy children at the age ranging from 8 to 15 years. The following results were thus obtained. In this instance, 50 healthy children matched by age were taken as controls.
1) Initial Immunization: Two intradermal injections of 0.1cc at the interval of 1 week demonstrated a significant rise in the hemagglutination inhibition titer (HVJ-HIT) in 5 out of 48 vaccinated cases (10.4%). In all of the cases, the complement fixation titer (HVJ-CFT) was negative even at the dilution of 1.2.
2) 1st Booster Immunization: As the results of the intradermal injection of 0.5cc 3 months after the initial immunization, a significant rise in the HVJ-HIT was recognized in 20 out of 47 vaccinated cases (42.6%). In all cases, no significant fluctuation in the HVJ-CFT was recognized.
3) 2nd Booster Immunization: As the results of 2 intradermal injections of 0.5cc each at the interval of 1 week 7 months after the 1st booster immunization, a significant rise in the HVJ-HIT was noted 17 days later in 21 out of 39 vaccinated cases (53.8%). Besides, a significant rise in the HVJ-CFT was noted in 13 out of 39 vaccinated cases (33.3%). One month later, both the HVJ-HIT and HVJ-CFT showed a tendency of falling, and all cases showed almost the same titer as that prior to the immunization 4 months later.
4) No statistically significant correlation was recognized between the infection of influenza A/Asia/57, which occured immediately after the 2nd booster immunization, and the antibody production effect, and between the mumps infection in the past and the antibody production effect of HVJ vaccine.
5) As side reaction of the immunization, excepting 1 case each of fever and vomiting after the 1st booster immunization, no serious general reaction was recognized at all. Further, all of the local reactions were only transient.
6) As stated in the above, in view of the high rate of antibody production effect and only slight side reactions, the inoculation of Merzonin inactivated HVJ (Obayashi strain) vaccine gave a favorable results comparable to those reported in the past about influenza vaccine.
