Abstract
Virus growth in several organs of mice after intranasal, intracerebral and intraperitoneal inoculations of influenza virus, PR 8, was first studied.
Even the inoculum was given from parenteral routes, the highest growth was obtained in lung among the organs tested. The mouse here used was three-weeks-old one and the virus titer in lung after intraperitoneal and intracerebral inoculations of large dosis of virus was just comparable to that obtained after inhalation of the small inoculum. In spite of such good growth, mice did not succumb after parenteral injections and sudden fall of virus titer in the lung was remarkable on the fifth day. Early and high antibody rise at these occasions was correlated to this sudden fall of virus titer.
The significance of hemagglutinins with low infectivity detectable in kidney and liver particularly at the time of parenteral inoculations was discussed.
