Myocardial Infarction with Mitral Regurgitation in a Dog

Takeo MINAMI; Yoshito WAKAO; Makoto MUTO; Toshifumi WATANABE; Koichiro NISHIDA; Tatsuo SUZUKI; Mitsugi TAKAHASHI; Takayuki YACHIKU

doi:10.11276/jsvc1984.19.103

Takeo MINAMI, Yoshito WAKAO, Makoto MUTO, Toshifumi WATANABE, Koichiro NISHIDA, Tatsuo SUZUKI, Mitsugi TAKAHASHI, Takayuki YACHIKU

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JOURNAL FREE ACCESS

1986 Volume 19 Issue 19 Pages 103-114

DOI https://doi.org/10.11276/jsvc1984.19.103

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Published: 1986 Received: - Available on J-STAGE: September 17, 2009 Accepted: - Advance online publication: - Revised: -
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Date of correction: September 17, 2009 Reason for correction: - Correction: TITLE Details: [in Japanese]

Date of correction: September 17, 2009 Reason for correction: - Correction: CITATION Details: Wrong : 1) BECKER, L. C., E. H. SCHUSTER, B. I. JUGDUTT, G. M. HUTCHINS and B. H. BULKLEY (1983): Relationship between myocardial infarct size and occluded bed size in the dog: Difference between left anterior descending and circumflex coronary artery occlusions. Circulation. 67, 549-557.
2) FREGIN, G. F., H. LUGINBUHL and F. GUARDA (1972): Myocardial infarction in a dog with bacterial endocarditis. J. Am. Vet. Med. Assoc., 160, 956-963.
3) GAILIUNAS, P. (1958): Calcification of arteries in young cattle-case report. J. Am. Vet. Med. Assoc., 15, 533.
4) HOWE, B. B. and M. M. WINBURY (1973): Effect of pentrinitrol, nitroglycerin and propranolol on small vessel blood content of the canine myocardium. J. Phr. Exp. Ther. 180, 647-656.
5) ICHIHARA, K. and Y. ABIKO (1975): Differencn between endocardial and epicardial utilization of glycogen in the ischemic heart. Am. J. Physiol., 229, 1585-1589.
6) ICHIHARA, K. and Y. ABIKO (1977): Inhibi: tion of endo- and epicardial glycogenolysis by propranolol in ischemic hearts. Am. J. Physiol., 232. H 349-H 353.
7) IRRIN, R. G. and F. R. COBB (1977): Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in awake dogs. Circulation, 155, 825-832.
8) JAFFE, K. R. and G. R. BOLTON (1974): Myocardial infarction in a dog with complete heart block. Vet. Med. Small Anim. Clin., 69, 197-200.
9) LANGER, P. H., T. DEMOTT and M. HUSSEY (1966): High fidelity electrocardiography: Effect of induced localized myocardial injury in the dog. Am. Heart J., 71, 790-796.
10) LIU, S. K., L. P. TILLEY, J. P. TAPPE and P. R. Fox (1986): Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983), J. Am. Vet. Med. Assoc., 189, 227-232.
11) LINDSAY, S. (1952): Arteriosclerosis in the dog. I. Spontaneous lesions in the aorta and the coronary arteries. Arch. Pathol., 53, 281-300.
12) LINDSAY, S. (1952): Arteriosclerosis in the dog. III. Aortic, cardiac and other vascular lesions in thyroidectomized-hypophyseetomized dogs. Arch. Pathol., 54, 573-591.
13) PENDLETON, R., D. J. NEWMAN., S. S. SHERMAN., E. G. BRANN and W. E. MAYA (1972): Effect of propranolol upon the hemoglobinoxygen dissociation curve. J. Pharm. Exp. Ther., 180, 647-656.
14) REIMER, K. A. (1973): Reduction by propranolol of myocardial necrosis following temporary coronary occlusion in dogs. Circ. Res., 33, 353-363.
15) WEIRICH, W.E., G.E. BISGARD., J.A. WILL., G.G. ROWE (1971): Myocardial infarction and pulmonic stenosis in a dog. J. Am. Vet. Med. Assoc., 159, 315-319.
16) WIT, A. L. and J. T. BIGGER (1975): Possible electrophysiological mechanisms for lethal and infarction. Circulation, 51-52 (suppl.3), 96-115.

Right : 1) BECKER, L. C., E. H. SCHUSTER, B. I. JUGDUTT, G. M. HUTCHINS and B. H. BULKLEY (1983): Relationship between myocardial infarct size and occluded bed size in the dog: Difference between left anterior descending and circumflex coronary artery occlusions. Circulation. 67, 549-557.
2) FREGIN, G. F., H. LUGINBUHL and F. GUARDA (1972): Myocardial infarction in a dog with bacterial endocarditis. J. Am. Vet. Med. Assoc., 160, 956-963.
3) GAILIUNAS, P. (1958): Calcification of arteries in young cattle-case report. J. Am. Vet. Med. Assoc., 15, 533.
4) HOWE, B. B. and M. M. WINBURY (1973): Effect of pentrinitrol, nitroglycerin and propranolol on small vessel blood content of the canine myocardium. J. Phr. Exp. Ther. 180, 647-656.
5) ICHIHARA, K. and Y. ABIKO (1975): Differencn between endocardial and epicardial utilization of glycogen in the ischemic heart. Am. J. Physiol., 229, 1585-1589.
6) ICHIHARA, K. and Y. ABIKO (1977): Inhibition of endo- and epicardial glycogenolysis by propranolol in ischemic hearts. Am. J. Physiol., 232. H 349-H 353.
7) IRRIN, R. G. and F. R. COBB (1977): Relationship between epicardial ST-segment elevation, regional myocardial blood flow, and extent of myocardial infarction in awake dogs. Circulation, 155, 825-832.
8) JAFFE, K. R. and G. R. BOLTON (1974): Myocardial infarction in a dog with complete heart block. Vet. Med. Small Anim. Clin., 69, 197-200.
9) LANGER, P. H., T. DEMOTT and M. HUSSEY (1966): High fidelity electrocardiography: Effect of induced localized myocardial injury in the dog. Am. Heart J., 71, 790-796.
10) LIU, S. K., L. P. TILLEY, J. P. TAPPE and P. R. Fox (1986): Clinical and pathologic findings in dogs with atherosclerosis: 21 cases (1970-1983), J. Am. Vet. Med. Assoc., 189, 227-232.
11) LINDSAY, S. (1952): Arteriosclerosis in the dog. I. Spontaneous lesions in the aorta and the coronary arteries. Arch. Pathol., 53, 281-300.
12) LINDSAY, S. (1952): Arteriosclerosis in the dog. III. Aortic, cardiac and other vascular lesions in thyroidectomized-hypophyseetomized dogs. Arch. Pathol., 54, 573-591.
13) PENDLETON, R., D. J. NEWMAN., S. S. SHERMAN., E. G. BRANN and W. E. MAYA (1972): Effect of propranolol upon the hemoglobinoxygen dissociation curve. J. Pharm. Exp. Ther., 180, 647-656.
14) REIMER, K. A. (1973): Reduction by propranolol of myocardial necrosis following temporary coronary occlusion in dogs. Circ. Res., 33, 353-363.
15) WEIRICH, W.E., G.E. BISGARD., J.A. WILL., G.G. ROWE (1971): Myocardial infarction and pulmonic stenosis in a dog. J. Am. Vet. Med. Assoc., 159, 315-319.
16) WIT, A. L. and J. T. BIGGER (1975): Possible electrophysiological mechanisms for lethal and infarction. Circulation, 51-52 (suppl.3), 96-115.

Abstract

Myocardial infarction with mitral regurgitation was diagnosed in a 13-year-old English setter. At the first medical examination, systolic murmurs in the mitral area were recorded by the phonocardiogram. Ventricular premature contractions and fushion beats were recorded on the electrocardiogram(ECG). After ECG examination, the dog was treated immediately with the antiarrhythmic drug.
On the first day of treatment, the dog had a good response to the treatment. Clinical signs and ECG findings were recovered. On the 6th day ventricular tachycardia occurred. On the 7th day, the dog had no response with any antiarrhythmic drug and died of ventricular arrhythmia.
Postmortem examination revealed thrombus in the cranial descending coronary artery (ventral interventricular branch of the left coronary) and left circumflex coronary artery (circumflex branch). Ischemic changes were also observed in the left anterior papillary muscle. The mitral valve leaflets were severely thickened. Calcification was seen in the sinus of Valsalva.

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