Effects of dopamine on the hepatic circulation in the dog

Mitsuya YAMAMOTO; Makoto WASHIZU; Gen KINOSHITA; Kunito KOBAYASHI; Kazunori MISAKA; Tsukimi WASHIZU; Hiromitsu ORIMA; Shigekatsu MOTOYOSHI

doi:10.11276/jsvc1984.26.10

Mitsuya YAMAMOTO, Makoto WASHIZU, Gen KINOSHITA, Kunito KOBAYASHI, Kazunori MISAKA, Tsukimi WASHIZU, Hiromitsu ORIMA, Shigekatsu MOTOYOSHI

Author information

Mitsuya YAMAMOTO
Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
Makoto WASHIZU
Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
Gen KINOSHITA
Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
Kunito KOBAYASHI
Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
Kazunori MISAKA
Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
Tsukimi WASHIZU
Department of Clinical pathology, Nippon Veterinary and Animal Science University
Hiromitsu ORIMA
Department of Radiology, Nippon Veterinary and Animal Science University
Shigekatsu MOTOYOSHI
Department of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

JOURNAL FREE ACCESS

1993 Volume 26 Issue 1 Pages 10-16

DOI https://doi.org/10.11276/jsvc1984.26.10

Details

Published: 1993 Received: February 01, 1993 Available on J-STAGE: September 17, 2009 Accepted: September 25, 1993 Advance online publication: - Revised: -
Correction information
Date of correction: September 17, 2009 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Veterinary Medical TeachingHospital
2) Department of Clinical pathology
3) Department of Radiology
4) Department of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

Right :
1) Veterinary Medical TeachingHospital, Nippon Veterinary and Animal Science University
2) Department of Clinical pathology, Nippon Veterinary and Animal Science University
3) Department of Radiology, Nippon Veterinary and Animal Science University
4) Department of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

Date of correction: September 17, 2009 Reason for correction: - Correction: CITATION Details: Wrong : 1) GREENWAY, C. V. and STARK, R. D. (1971) : Hepatic vascular bed. Physiological. Reviews., 10, 23-65.
4) GOLDBERG, A. H. (1970) : Anesthesia and hepatic blood flow. Anesthesia and the Liver., Little Brown, Boston., 315-421.
5) BEREGOVICH, 7. (1974) : Dose-related hemodynamic and renal effects of dopamine in congestive heart failure. Am. Heart. J., 87, 550-557.
6) GOLDBERG, L. I. (1972) : Cardiovascular and renal actions of dopamine; Potential clinical applications. Rharmacol. Rev., 24, 1-23.
7) ROME, N. W. and GOLDBERG, L. I. (1975) : Comparative systemic and regional hemodynamic effects of dopamine and dobutamine. Amer. Heart. J., 90, 340-345.
9) JOHNSON, P. C. (1986) : Autoregulation of blood flow. Circ. Res., 59, 483-495.
10) RICHARDSON, P. D. I. and WITHRINGTON, P. G. (1981) : Liver blood flow, 1. Intrinsic and nervous control of liver blood flow Gastroenterology., 81, 159-173.
11) LAUTT, W. W. (1980) : Control of hepatic arterial blood flow ; independence from liver metabolic activity. Am. J. Physiol., 239, H559-H564.
12) LAUTT, W. W. (1983) : Relationship between hepatic blood flow and overall metabolism; the hepatic arterial buffer response. Fed. Proc., 42, 1662-1666.
13) LAUTT, W. W. (1985) : Mechanism and role of intrinsic regulation of hepatic arterial blood flow ; the hepatic arterial buffer response. Am, J. Physiol., 249, G549-G556.
15) ROYTBLAT, L., GELMAN, S., BRADLEY, E. L., HENDERSON, T, and PARKS, D. (1990) : Dopamine and hepatic oxygen supply-demand relationship. Can. J. Physiol. Pharmacol., 68, 1165-1169.

Right : 1) GREENWAY, C. V. and STARK, R. D. (1971) : Hepatic vascular bed. Physiological. Reviews., 10, 23-65.
4) GOLDBERG, A. H. (1970) : Anesthesia and hepatic blood flow. Anesthesia and the Liver., Little Brown, Boston., 315-421.
5) BEREGOVICH, J. (1974) : Dose-related hemodynamic and renal effects of dopamine in congestive heart failure. Am. Heart. J., 87, 550-557.
6) GOLDBERG, L. I. (1972) : Cardiovascular and renal actions of dopamine; Potential clinical applications. Rharmacol. Rev., 24, 1-23.
7) ROME, N. W. and GOLDBERG, L. I. (1975) : Comparative systemic and regional hemodynamic effects of dopamine and dobutamine. Amer. Heart. J., 90, 340-345.
9) JOHNSON, P. C. (1986) : Autoregulation of blood flow. Circ. Res., 59, 483-495.
10) RICHARDSON, P. D. I. and WITHRINGTON, P. G. (1981) : Liver blood flow, 1. Intrinsic and nervous control of liver blood flow Gastroenterology., 81, 159-173.
11) LAUTT, W. W. (1980) : Control of hepatic arterial blood flow ; independence from liver metabolic activity. Am. J. Physiol., 239, H559-H564.
12) LAUTT, W. W. (1983) : Relationship between hepatic blood flow and overall metabolism; the hepatic arterial buffer response. Fed. Proc., 42, 1662-1666.
13) LAUTT, W. W. (1985) : Mechanism and role of intrinsic regulation of hepatic arterial blood flow ; the hepatic arterial buffer response. Am, J. Physiol., 249, G549-G556.
15) ROYTBLAT, L., GELMAN, S., BRADLEY, E. L., HENDERSON, T, and PARKS, D. (1990) : Dopamine and hepatic oxygen supply-demand relationship. Can. J. Physiol. Pharmacol., 68, 1165-1169.

Abstract

We studied the effects of the intravenous infusion of dopmine on hepatic circulation at doses of 3, 7 and 15μg/kg/min. Six mongrel dogs weighing 19.1±6.1kg were studied under sodium pentobarbital anesthesia. Cardiac output was measured by thermodilution methods. Portal venous blood flow (PVBF) and hepatic arterial blood flow (HABF) were measured by an electromagnetic flowmeter. Hepatic oxygen supply and consumption were calculated from the blood flow and the oxygen contents.
Dopamine at all doses caused a significant increase in PVBF and a significant decrease in HABF. However, dopamine at doses of 3 and 7μg/kg/min demonstrated no significant changes in the total hepatic blood flow (THBF). Dopamine at a dose of 3μg/kg/min showed no effects on the hepatic and systemic oxygen supply-demand relationship. Dopamine at a dose of 7μg/ kg/min resulted in increased in the systemic oxygen supply and consumption under a fixed oxygen extraction ratio. Dopamine at a dose of 15μg/kg/min caused a significant increase in THBF accompanied by an increased systemic oxygen consumption and an increased systemic oxygen extraction ratio.
From these results, it is suggested that dopamine at doses of 3 and 7μg/kg/min has minimum effects on the hepatic circulation and oxygen supply-demand relationship, but that dopamine at a dose of 7μg/kg/min is the most effective for improvement of the systemic circulation and oxygen supply-demand relationship.

Corresponding author

Correction information

Register with J-STAGE for free!