Effects of dobutamine on the hepatic circulation in dogs

Kimiaki DOI; Makoto WASHIZU; Gen KINOSHITA; Kunito KOBAYASHI; Kazunori MISAKA; Tsukimi WASHIZU; Hiromitsu ORIMA; Shigekatsu MOTOYOSHI

doi:10.11276/jsvc1984.26.17

Kimiaki DOI, Makoto WASHIZU, Gen KINOSHITA, Kunito KOBAYASHI, Kazunori MISAKA, Tsukimi WASHIZU, Hiromitsu ORIMA, Shigekatsu MOTOYOSHI

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Kimiaki DOI
Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
Makoto WASHIZU
Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
Gen KINOSHITA
Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
Kunito KOBAYASHI
Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
Kazunori MISAKA
Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
Tsukimi WASHIZU
Department of Clinical pathology, Nippon Veterinary and Animal Science University
Hiromitsu ORIMA
Department of Radiology, Nippon Veterinary and Animal Science University
Shigekatsu MOTOYOSHI
Deparment of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

JOURNAL FREE ACCESS

1993 Volume 26 Issue 1 Pages 17-23

DOI https://doi.org/10.11276/jsvc1984.26.17

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Published: 1993 Received: February 01, 1993 Available on J-STAGE: September 17, 2009 Accepted: September 25, 1993 Advance online publication: - Revised: -
Correction information
Date of correction: September 17, 2009 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Veterinary Medical Teaching Hospital
2) Department of Clinical pathology
3) Department of Radiology
4) Deparment of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

Right :
1) Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University
2) Department of Clinical pathology, Nippon Veterinary and Animal Science University
3) Department of Radiology, Nippon Veterinary and Animal Science University
4) Deparment of Internal Medicine School of Veterinary Medicine, Nippon Veterinary and Animal Science University

Date of correction: September 17, 2009 Reason for correction: - Correction: CITATION Details: Wrong : 1) PREISER, J. C., ARMISTEAD, C., MINH, T. L., and VINCENT, J.L. (1989): Increase in oxygen supply during experimental septic shock: The effects of dobutamine versus dopexamine. J. Crit., Care. 4, 40-44.
2) SOEMAKER, W. C. (1991): Tissue perfusion and oxygenation: A primary problem in acute circulatory failure and shock states. Crit. Care. Med., 19, 595-596.
3) SOEMBKER, W. C., APPEL, P. L., and KRAM, H. B. (1988): Tissue oxygen debt as a determinant of lethal and nonlethal postoperative organ failure. Crit. Care. Med., 16, 1117-1120.
4) ROBIE, N. W., NUTTER, D. O., MOODY, C.,and MCNAY, J. L. (1974): In vivo analysis of adrenergic receptor activity of dobutamine. Circ. Res., 34, 663-671.
5) TUTTLE, R. R., and MILLS, J. (1975): Dob-utamine: Development of a new catecholamine to selectively increase cardiac contractility. Circ. Res., 36, 185-196.
6) TUTTLE, R. R., POLLOCK, G. D., TODD, G., and TUST, R. (1973): Dobutamine: Containment of myocardial infaraction size by a new inotropic agent. Circulation, 48, IV-132.
13) LAUTT, W. W., and GREENWAY, C. V.(1987): Conceptual review of the hepatic vascular bed. Hepatology, 7, 952-963.
14) RICHARDSON, P. D. I., and WITHRINGTON, P. G. (1981): Liver blood flow, I. Intrinsic and nervous control of liver blood flow. Gastroenterology, 81, 159-173.
15) GREENWAY, C. V,, and STARK, R. D. (1971): Hepatic vascular bed. Physiological. Reviews., 51, 23-65.
16) LAUTT, W. W. (1985): Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am. J. Physiol., 249, G549-G556.
17) RICHARDSON, P. D. I., and WITHRINGTON, P. G. (1981): Liver blood flow, II. Effects of drugs and hormones on liver blood flow. Gastroenterology, 81, 856-875.

Right : 1) PREISER, J. C., ARMISTEAD, C., MINH, T. L., and VINCENT, J.L. (1989): Increase in oxygen supply during experimental septic shock: The effects of dobutamine versus dopexamine. J. Crit., Care. 4, 40-44.
2) SOEMAKER, W. C. (1991): Tissue perfusion and oxygenation: A primary problem in acute circulatory failure and shock states. Crit. Care. Med., 19, 595-596.
3) SOEMBKER, W. C., APPEL, P. L., and KRAM, H. B. (1988): Tissue oxygen debt as a determinant of lethal and nonlethal postoperative organ failure. Crit. Care. Med., 16, 1117-1120.
4) ROBIE, N. W., NUTTER, D. O., MOODY, C.,and MCNAY, J. L. (1974): In vivo analysis of adrenergic receptor activity of dobutamine. Circ. Res., 34, 663-671.
5) TUTTLE, R. R., and MILLS, J. (1975): Dobutamine: Development of a new catecholamine to selectively increase cardiac contractility. Circ. Res., 36, 185-196.
6) TUTTLE, R. R., POLLOCK, G. D., TODD, G., and TUST, R. (1973): Dobutamine: Containment of myocardial infaraction size by a new inotropic agent. Circulation, 48, IV-132.
13) LAUTT, W. W., and GREENWAY, C. V.(1987): Conceptual review of the hepatic vascular bed. Hepatology, 7, 952-963.
14) RICHARDSON, P. D. I., and WITHRINGTON, P. G. (1981): Liver blood flow, I. Intrinsic and nervous control of liver blood flow. Gastroenterology, 81, 159-173.
15) GREENWAY, C. V,, and STARK, R. D. (1971): Hepatic vascular bed. Physiological. Reviews., 51, 23-65.
16) LAUTT, W. W. (1985): Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am. J. Physiol., 249, G549-G556.
17) RICHARDSON, P. D. I., and WITHRINGTON, P. G. (1981): Liver blood flow, II. Effects of drugs and hormones on liver blood flow. Gastroenterology, 81, 856-875.

Abstract

Effect of intravenous infusion of dobutamine on hepatic circulation at doses of 5, 10, and 15μg/kg/min were studied in 6 mongrel dogs under pentobarbital sodium anesthesia. Hepatic arterial and portal venous blood flows were measured. Dobutamine increased the heart rate and the cardiac index, but decreased the systemic vascular resistance with a dose-dependence. Each dose of dobutamine did not change the mean arterial pressure. The 5μg/kg/min-adminstered group demonstrated an increased total hepatic blood flow accompanied by increased hepatic arterial and portal venous blood flows. The 10μg/kg/min-administered group showed an increased total hepatic blood flow accompanied by an increased portal venous blood flow with no change in hepatic arterial blood flow. The 15μg/kg/min-infused group showed an increased total hepatic blood flow accompanied by an increased portal venous blood flow and a decreased hepatic arterial blood flow. Portal and hepatic venous pressures were not changed with no relation to dose-dependence. Hepatic oxygen supply was increased with a dose-dependence, but the hepatic oxygen consumpution was maintained at the control level. Hepatic oxygen extraction ratio was decreased with a dose-dependence. To summarize the data, dobutamine significantly improves the hepatic circulation, accompanied by a hepatic oxygen supply increment.

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