Abstract
Pulmonary edema is often encountered as an acute symptom of left insufficiency in mitral regurgitation. Diuretics or vasodilator is generally administered to improve pulmonary congestion. Among the nitroglycerin formations, the rapid acting sublingual tablets were selected in this study. A new administration route of sublingual tablets were devised into preputial cavity in male and into vagina in female, Preclinically this administration was performed in clinically healthy dogs. The cardio-vascular behavior after this preclinical administrations to the dogs were almost same of those after sublingual administration to human. We considered that this administration was clinically applicable. Relatively mild cases of pulmonary edema with clinical symptoms, were initially treated with intra-preputial or intra vaginal administration of nitroglycerin sublingual tablets. Remarkable clinical improvement was recognized in these cases.
