DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain

Abstract

The effects of Choto-san on gene expression in the dementia model rat brain were studied using a DNA microarray system. Choto-san inhibited the expression of 181 genes that has been enhanced by permanent occlusion of the bilateral common carotid arteries (2VO). Choto-san also reversed the expression inhibition of 32 genes induced by 2VO. These results may suggest that Choto-san, which has been therapeutically used as an antidementive drug, shows therapeutic effects through gene expression changes.