Abstract
A new original formulation containing crude drugs used for self-medication was developed by a joint project of the Federation of Pharmaceutical Inductries Association in Toyama, Toyama Prefecture (Toyama Prefectural Institute for Pharmaceutical Research) and Toyama Medical and Pharmaceutical University. This formulation consists of 11 crude drugs. In this study, the effect of this formulation on model animals with a life-style related disease was studied. Spontaneously hypertensive rats added to hypercholesterol diet were given this formulation in chow for 8 weeks. The results indicated that this formulation caused a decrease in vasocontraction induced by phospholipase A2. Plasma triglyceride and lipid peroxide were significantly decreased, but blood pressure was not changed. Furthermore spontaneously diabetic rats were given this formulation in chow for 4 weeks. The results indicated that this formulation caused a decrease in plasma triglyceride, lipid peroxide and fibrinogen significantly, but blood glucose was not changed. From these results, it was supposed that this formulation exerted the suppression effect of vasocontraction, improvement effect of fatty metabolism and decrease effect of fibrinogen. This formulation is thought to be a useful drug to prevent the vasocomplication based on life-style related disease.
